Final ProgramCPSA 2012
Transforming Drug Discovery & Development Through Innovation:
Past, Present and Future
October 1 - 4, 2012
Sheraton Bucks County Hotel
Langhorne, PA
Session Synopsis
Tuesday, 3:15 pm - 4:45 pm
Trends in Metabolite Identification
Discussion Leader: Natalia Penner, Biogen Idec
Metabolism plays an important role in overall safety profile of a drug; therefore, regulatory authorities and the pharmaceutical industry have paid much attention to how and when the characterization of human metabolites should occur. Metabolite profiling and identification techniques have undergone quick development in the past decade and were discussed in numerous publications. This session will provide a historical overview of metabolism studies followed by an active discussion of the current state and future of this field. The goal is to sparkle discussion – during the session and afterwards! - about where are we going and what needs to be done.
Presenters:
What is the Purpose of Human ADME Studies?
Ronald White, XenoBiotic Laboratories
Current Strategic Leverage of Radiolabel Metabolism Studies: Human-Only? Rat-Early? Active Metabolites, Reactive Metabolites, and MIST
Scott Obach, Pfizer
Maximizing the Value of Drug Metabolism Studies–Where To Go From Here?
Russell Mortishire-Smith, Johnson & Johnson
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