Clinical & Pharmaceutical Solutions through Analysis
October 5 - 8, 2015
Sheraton Bucks County Hotel, Langhorne, PA
Where Technology and Solutions Meet!
Clinical & Pharmaceutical Solutions through Analysis
October 5 - 8, 2015
Sheraton Bucks County Hotel, Langhorne, PA
Where Technology and Solutions Meet!
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CPSA USA 2015Getting Medicines to Patients Faster by Eliminating the Bottlenecks in Drug Discovery and DevelopmentPreliminary Program Monday | Tuesday | Wednesday | ThursdayUpdated September 24, 2015 Monday October 5
7:30 am - 8:30 am
Princeton Foyer Registration Open
8:30 AM - 4:00 PM
Princeton I Short Courses
Protein ID and Biomarker Analysis by Mass Spectrometry: Challenges and Solutions for Quantification and Differential Analysis
Princeton II
New! How to Teach an Old Dog New Tricks; The Use of Traditional and Novel Methods, Practices, Technologies to Quantify Protein Therapeutics in a Regulated Environment
Lehigh
Building a Better Clinical Mass Spectrometry Lab:
TBA
Human Pharmacokinetic Prediction and Approaches to Identify Rate Determining Step of Drug Absorption and Elimination: Industrial Perspective
7:30 AM - 9:30 AM
Tyler State Park Newtown, PA Contact Nicole Matz for more information.
10:00 AM - 3:00 PM
Makefield Highlands Golf Club, Yardley, PA Tee Time - 10:00 AM
12:00 pm - 4:00 pm
Villanova Amphitheater Molecular Discovery Users Meeting Discussion Leader: Ismael Zamora, Molecular Discovery Automated Soft-Spot Identification: Success Rate, Limitations, Code Logic and Functionality To be announced What is Molecular Discovery Working on Now in Order to Get More Knowledge from the Same Data
4:30 pm - 5:30 pm
University I/II
Executive Roundtable Sponsored by McKinley Scientific Discussion Leaders: Lucinda Cohen, Merck and Shane Needham, Alturas Analytics
6:00 pm - 9:00 pm
University I/II Sponsor's Reception & Dinner Hosted by SCIEX Distinguished Lecture Series 
Fetal Alcohol Exposure - A 30 Year Search for a Reliable Biomarker Tuesday October 6
7:30 am - 8:30 am
University Foyer Registration & Continental Breakfast
7:30 am - 8:30 am
University I/II Graduate Student/Mentor Breakfast
8:30 am - 9:00 am
University I/II Welcome & Opening Remarks Opening Remarks – Disease is the Enemy! 
Welcome 
Format, Objectives, Opening Remarks 
Naidong Weng
9:00 am - 9:45 am
University I/II Plenary Lecture 
Mechanism Based Drug Disposition – Building Quality into Our Product Pipeline
10:00 am - 11:45 am
Parallel Sessions
Villanova Amphitheater
TRACK I: Symposium Session Future Needs of Mass Spectrometry in Clinical Sciences Discussion Leaders: Timothy Garrett, University of Florida and Kenneth Lewis, OpAns Achieving Widespread Adoption of MS in the Clinical Laboratory: What Will It Really Take? Using MS to Screen Multiple Metabolites: How to Design Your Assay for the Clinic
Digitized LC-MS as an Enabling Tool on the Path to Precision Healthcare
Understanding Complex Lipid Metabolism through Quantitative Lipidomics
Princeton I/II
TRACK II: Colloquium Session PBPK Modeling PBPK Model Guided Drug Development and Labeling Optimization A Systems Platform to Predict Pharmacokinetics of Liver Transporter Substrates Minimal Physiologically-Based Pharmacokinetic (mPBPK) Model for a Monoclonal Antibody against Interleukin-6 in Mice with Collagen-Induced Arthritis
12:00 pm - 1:00 pm
University I/II Sponsored Lunch & Roundtables Sponsored by Shimadzu Scientific Instruments LCMS-8060: Changes Everything Ruth Verplaetse, Q2 Solutions
1:00 pm - 3:00 pm
University Foyer Poster Session & Roundtables Discussion Leaders: Mark Cancilla, Merck; Helene Cardasis, Thermo Fisher Scientific; Matthew Szapacs, GlaxoSmithKline; Tracie Williams, CDC
3:15 pm - 4:45 pm
Parallel Sessions
University I
TRACK III: Symposium Session A Tough Nut to Crack: Bringing New Analytical Approaches to the Clinic Successfully Translating Global Metabolomics to Clinical Diagnostics Simplifying Complex Proteomic Workflows for Larger Scale and Speed From Discovery to Patient – A Case Study
University II
TRACK IV-a - Colloquium Session Tiered Approach/Scientific Validation in Bioanalysis – Reaching out our Stakeholders in QA, Clinical and Preclinical PK Introduction and aim Principles and Status Update of Scientific Validation/Tiered Approach in Bioanalysis Contribution related to a QA Perspective on Scientific Validation/Tiered Approach Fit-for-Purpose Bioanalytical Data in Preclinical Phase Contribution Related to a Clinical PK Perspective on Scientific Validation/Tiered Approach Panel Discussion
Lehigh
TRACK IV-b - Colloquium Session Structure Identification Isolation and Structure Elucidation in the Development Environment within Pharma Challenges in Impurity Isolation and Identification at a Contract Research Lab
4:45 pm - 5:15 pm
2nd Floor Lobby Let Them Eat Cake!
Don Chace, Pediatrix Analytical
5:00 pm - 6:00 pm
Social Hour & Sponsored Workshops
Princeton I
WORKSHOP Sponsored by SCIEX Large Molecule Bioanalysis: LC-MS or ELISA? Improving Sensitivity in Bio-Analysis using microLC
Princeton II
WORKSHOP Sponsored by McKinley Scientific Daily Performance Monitoring Differential Mass Spectrometry Platform for Personalized Healthcare Infinite Speed and LC/MS Throughput with Digital LC Technologies Informatics for Personalized Healthcare
Villanova Amphitheater
WORKSHOP Sponsored by Waters Corporation David Heywood, Waters Corporation
Lehigh
WORKSHOP Sponsored by PharmaCadence Analytical Services, LLC IAC and Digestion with a Single Reagent A Controlled Flow 96 Well Plate for Full Automation of Antibody Capture and Protein Digestion Workflow
6:30 pm - 9:00 pm
Sponsor Hospitality & Evening Workshops
University I
High Resolution Accurate Mass Quantitation Summit Sponsored by Thermo Scientific Discussion Leaders: Jack Henion, Q2 Solutions and Jonathan Josephs, Thermo Scientific Past Present and Future of Interrogating Biological Samples: How HRAM has Become an Essential and Integral Component of the Analytical Arsenal Panel Discussion
University II
Microsampling Summit Sponsored by Drummond Scientific and McKinley Scientific Discussion Leaders: Qin Ji, Bristol-Myers Squibb and Olga Kavetskaia, AbbVie An Integrated Strategy for Implementation of Dried Blood Spots in Clinical Development Programs Small samples with a BIG impact; where is microsampling today?
Comparative Studies for Dried Blood Spot Sampling: Design, Conduct and Statistical Data Analysis
Panelists: Wednesday October 7
7:30 am - 8:30 am
University Foyer Registration & Continental Breakfast
8:30 am - 10:00 am
University I/II Symposia & Roundtables The Future of Mass Spectrometry for Clinical Protein Biomarker Determination (20/20 Vision) Discussion Leader: Randall Nelson, Arizona State University Next Horizon of Immunoaffinity LC-MS/MS for Protein Biomarkers The Future is Now - Monitoring Insulin Levels for Diabetes Clinical Care With High Precision Using Mass Spectrometry Mass Spectrometric Immunoassays for Discovery, Verification, and Validation of Proteoform Biomarkers
10:15 am - 11:45 am
Parallel Sessions
Villanova Amphitheater
TRACK V: Symposium Session Rare Diseases Gaucher Disease and Parkinsonism: Insights from a Rare Disease Analytical Aspects of Phenotypic Screening in Drug Discovery for Rare Diseases A Pediatrician's Perspective: Insight into the Diagnosis and Treatment of Metabolic Diseases - Amino Acids & Organic Acids as Biomarkers.
Princeton I/II
TRACK VI-a: Colloquium Session Innovation Boot Camp Tim Olah, Bristol-Myers Squibb Jim Yergey, Yergey Consulting
Lehigh
TRACK VI-b: Colloquium Session Metabolite Identification and Databases: Industrial Workflows and Emerging Trends Optimized Workflow for a Metabolic Soft Spot Identification Assay How to Fit the DMS Dimension into Fluxomic Workflows To be announced
12:00 pm - 1:00 pm
Sponsored Lunch & Roundtable
University I & II
Sponsored by Agilent Technologies Stereospecific Drug Metabolite Analysis Using 2D LC/MS Q-TOF and SFC/QQQ
1:15 pm - 2:15 pm
Social Hour & Sponsored Workshops
Princeton I
WORKSHOP Sponsored by SCIEX Detect More Selectively with SelexION® Technology
Princeton II
WORKSHOP Sponsored by New Objective TBA TBA The Potential of Nanospray and Digitization to Improve Metabolomic Workflows
Villanova Amphitheater
WORKSHOP Sponsored by Waters Corporation Advances in IMS-enabled Workflows For Qualitative and Quantitative DMPK Studies Processing HDMS(e) Data in Mass-Metasite
2:30 pm - 3:30 pm
Parallel Sessions
University II
Innovator Award Session The Effects of Heat Stabilization and Euthanasia Methods on Free Fatty Acid Measurements in Rat Tissues A Lab Mobile Mass Spectrometer for High Fidelity Mass Analysis Around the Pharmaceutical Facility Identifying Proteins to which Small-Molecule Probes and Drugs Bind Differential Mass Spectrometry Workflow Leveraging Cloud Based Technologies Use of Cerex SPE cartridge technology for simplified IAC sample preparation Development and Application of the MASSPEC Algorithm for Structural Elucidation Utilizing Mass Spectral Data
Villanova Ampitheatre
Steven A. Hofstadler Graduate Student Session Inspiring Career Paths in the Sciences for Young Scientists Sponsored by McKinley Scientific, New Objective and OpAns Mentors: Direct Sampling of Adherent Cells Using Laser Ablation Electrospray Ionization Mass Spectrometry Identification of Sirtuin 5 Modulators by Droplet Microchip Electrophoresis Lipidomics of Liver Disease Higher Insight in Cellular Senescence: Defining a New Mass Window for Top Down Quantitative Proteomics
3:45 pm - 4:15 pm
Princeton I/II CPSA Award Presentations Sponsored by McKinley Scientific and New Objective Innovator Award Presentation Steven A. Hofstadler Graduate Student Award/Recognition Program Chair Recognition
4:15 pm - 5:45 pm
Princeton I/II
Keynote Lecture and Keynote Lecture "Kicking it Up a Notch” with New Spices in Clinical Chemistry: Multiple Metabolite, Micro Sampling and LC/MS 
Don Chace Distinguished Analytical Scientist Award Presentation Pigs 'n Blankets: Mass Spectrometry and the Continuum of Human Health 
Andy Hoofnagle
5:45 pm - 6:45 pm
University I & Lobby, 2nd Floor Lobby Exhibition & Social Hour
6:45 pm - 9:00 pm
University II Vendor Session - "Five Minutes of Fame" Hosted by Bernard Hirsh, Merrill Lynch Discussion Leaders: Mark Hayward, ITSP Solutions, Inc.; Matt Szapacs, GlaxoSmithKline; Nicole Donnelly, PharmaCadenceThursday October 8
7:30 am - 8:30 am
2nd Floor Lobby Registration & Continental Breakfast
8:30 am - 10:00 am
Princeton I/II Colloquia & Roundtables ADC/PDC Discussion Leaders: Wenying Jian, Janssen Research & Development and Jim Shen, Bristol-Myers Squibb The Role of Mass Spectrometry in Supporting the Development of Therapeutic Antibodies and Antibody-Drug Conjugates (ADC’s) ADC Bioanalysis by Immuno-Capture LC-MS/MS Hybrid Assays Next-Generation Drug Conjugates Using the Centyrin Alternative Scaffold
10:15 am - 11:45 am
Parallel Sessions
Villanova Amphitheater
Track VIII: Symposium Session Biomarkers From Start to Finish Discussion Leader: Alla Kloss, Genzyme X-Linked Adrenoleukodystrophy: Biomarkers for Newborn Screening and Development of New Therapies
Isotopic Labeling Strategies for Biomarker Discovery in Metabolomics
PD Biomarker Measurement by LC/MS/MS – Technological Advancements to Address Sensitivity and Throughput Challenges
Lehigh
Track VIII: Colloquium Session Traditional and Non-Traditional Strategies to Generate Drug Metabolites for Analytical Characterization Discussion Leaders: James Small, Merck Traditional Drug Metabolite Generation Schemes Non-Traditional Drug Metabolite Generation Schemes Role of Drug Metabolite Identification in Drug Discovery and Development
12:00 pm - 1:15 pm
Princeton I/II
Sponsored Lunch & Roundtables
Discussion Leaders: Tim Garrett, University of Florida and Petia Shipkova, Bristol-Myers Squibb LC-MS and Prenatal Metabolism from Population to Bench Improving Metabolomics Separations with Ion Mobility Mass Spectrometry
1:30 pm - 3:00 pm
Villanova Amphitheater Symposia & Roundtables New Alternative Instrumentation Discussion Leaders: Kevin Bateman, Merck and Rick King, PharmaCadence
3:00 pm
Adjourn |
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