Final ProgramCPSA 2011
Science and Technology Coming Together to Make a Difference
October 3 - 6, 2011
Bucks County Sheraton Hotel
Langhorne, PA
Poster Abstract #09
The Separation of Basic Analytes on a Polar-modified C18 HPLC Stationary Phase
Orochem Technologies, Inc.
The separation of basic organic compounds on typical C18 HPLC stationary phases is not always straightforward. Gradients, buffers, modifiers, and column temperature are some of the variables that are often used in the quest to separate closely related compounds with reasonable peak asymmetry. Orochem Technologies has introduced a new C18 HPLC stationary phase that contains specially designed polar sites, which permit excellent separations of difficult amine and amide mixtures. These separations can often be carried out using mobile phases based on blends of water and alcohols or water and acetonitrile without the need of buffers or modifiers. Although these stationary phases contain polar sites they retain their high hydrophobicity. These stationary phases, trade named Orosil™ Polar C18, are available in particle sizes of 1.7 micron for UHPLC applications; 3, 5, and 10 microns for typical analytical applications; and from 20 microns up to 300 microns for semi-prep, preparative, and SMB (simulated moving bed) applications.