Final ProgramCPSA 2011
Science and Technology Coming Together to Make a Difference
October 3 - 6, 2011
Buscks County Sheraton Hotel
Langhorne, PA
Conference Program
September 29, 2011
Monday, October 3 | |
8:30 am - 4:00 pm |
Short Courses - Bucks County Sheraton
Method Development for LC/MS: Traditional Approcahes and Emerging Trends
Small Molecule Biomarkers: Strategies for Method Development, Profiling and High Throughput Workflow Solutions in Drug Discovery
Analysis of Peptides Peptides and Proteins: Sample Prep to Identification and Quantitation |
9:00 am - 3:00 pm |
CPSA Golf Outing - Makefield Highlands Golf Club, Yardley, PA |
12:00 pm - 4:00 pm |
Pharmaceutical Sciences Workshop: Impurities and Degradants Characterization of Impurities and Degradants in Biologics Discovery and Development Effective Use of LC-MSn Molecular Fingerprinting for the Rapid Structure Identification of Pharmaceutical Impurities Analytical Challenges in Controlling Genotoxic Impurities To Isolate or Not: The Sometimes Circuitous Characterization of a Degradant |
4:30 pm - 5:30 pm |
Sponsored Workshop & Social |
6:00 pm - 9:00 pm |
Reception & Sponsor's Dinner New Chip to MicroLC Applications New microfluidic cHiPLC Applications for Higher throughput Method development and transfer for a range of linear velocities suitable to scale down to 1mm column IDs and beyond |
Tuesday, October 4 | |
7:30 am - 8:30 am | Registration & Continental Breakfast |
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7:30 am - 8:30 am |
Sponsored Breakfast Workshop Electronic Lab Notebook Special Interest Group |
8:30 am - 9:00 am |
Welcome
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CPSA USA 2011 Chair Roger Hayes, Ph.D. Cetero Research |
9:00 am - 9:45 am |
Plenary Lecture
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10:00 am - 11:45 am | Parallel Sessions |
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Parallel Track I
Biomarkers for Toxicity
Lipid Analysis in Mitochondria and Serum Using High Resolution LC-MS and HCD Fragmentation
Coupling Static and Kinetic Biomarkers in Order to Unravel Dyslipidemia
LC/MS Biomarker Assay Validation Using Surrogate Matrix and Surrogate Analyte Approaches
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Parallel Track II
Holy #$%@! What Have We Gotten Ourselves Into?
Carryover and Chromatographic Background Contributions: Are We Assessing Potential Bias Effects on Individual Sample Result and/or Batch Acceptance in Realistic (and Meaningful) Ways?
Pitfalls of Whole Blood Stability and Hemolytic Plasma Assessment in Bioanalysis
The Role of Compliance in "Non-Regulated" Studies Conducted by the Pharmaceutical Industry
Pre-Compliance in Early in vitro Drug Development
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12:00 pm - 1:00 pm |
Sponsored Lunch / Roundtables |
1:15 pm - 3:00 pm |
Poster Session / Roundtables
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2:00 pm - 3:00 pm | Sponsored Workshops LDTD with SelexION™ Technology and the QTRAP® 5500 System with Advanced Selectivity and High Throughput FTMS Small Molecule Imaging Workflow Metabolism Optimization: Future Needs and Emerging Workflows Workflows for Efficient Data Acquisition and Processing Application of Metabolite Identification Information for Drug Design Interactive Demonstration of Software Tools for Acquisition, Processing and Design A QbD-based Approach to LC Method Development |
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| Symposia & Rountable Discussion |
3:00 pm - 4:30 pm |
Metabolite Identification
Use of High Resolution Mass Spectrometry for Correct Structure Elucidation of Metabolites
Advances in Metabolite Profiling Software: An Evaluation of Mass-Metasite
Streamlining the Drug Discovery Biotransformation Workflow: HRMS, On-the-fly-MDF and Metabolite Pilot Software
A Comparison of Metabolic Profiles Following Targeted and Non-Targeted Analysis Using Q-Trap Technologies
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4:45 pm - 6:15 pm |
Innovation in Regulated Bioanalysis: Fact or Fantasy?
What is Innovation? The Case for Innovation in Drug Discovery Bioanalysis The Case for Innovation in Regulated Bioanalysis Group Arguement on Innovation in Bioanalysis |
6:30 pm - 9:00 pm |
Sponsor Hospitality & Workshops Beyond Sensitivity: New Solutions for Pharmaceutical Analysis Dried Blood Spot Summit History, Properties, Issues and Scope of Applications for the Filter paper as a Matrix for Specimen Collection and Analysis New Technologies for the Direct Analysis of Analytes and Enzyme activities in Dried Blood Spots The Dried "X" Spot - Beyond Newborn Screening DBS Implementation Strategies Towards Full Yet Flexible Automation of Dried Blood and Matrix Spot Analysis |
Wednesday, October 5 | |
7:30 am - 8:30 am | Registration & Continental Breakfast |
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7:30 am - 8:30 am |
Sponsored Breakfast Workshop
Isotope Solutions to Address Unmet Analytical Needs |
8:30 am - 10:30 am | Symposia & Roundtables |
Fast-to-Fail Paradigm Optimizing the Disposition Characteristics of New Chemical Entities Using HTS ADME Screens
Biochemical and Assay Screening Using High Throughput Mass Spectrometry Detection
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10:45 am - 12:15 pm | Parallel Sessions |
Parallel Track I Don't forget the "LC" in LC-MS/MS Moving Quantitative SRM-MS Toward a Faster Time-Frame: Evaluating Dual Columns and Microfluidic Chips for Peptide Quantification in Plasma
Single Molecule Detection and Analysis with Nanostructures | |
Parallel Track II
Pharma Perspective on Globalizing Bioanalysis
Globalizing Bioanalysis from a CRO Perspective: A Strategic Overview - Advantages and Challenges
Global Bioanalysis Consortium - An Update of Harmonization Activities
Immunogenicity Global Guidance Harmonization
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12:00 pm - 2:15 pm |
Exhibition - Where Technology and Solutions Meet! |
12:15 pm - 2:15 pm | Lunch & Learn Sessions Workshop
Transitioning Qual/Quant Platforms from Small Molecules to Biologics
New Horizons for MALDI-TOF MS: The MALDI Biotyper for Microbial Identification in Pharmaceutical Microbiology Business Management and Science in the 21st Century
Ajai Chaudhary, Merck High-Performance Nanospray: Technique & Technology Efficient Fractionation Strategies for LC-MS/MS in Proteomics Challenges of Dual Column Nanospray in Quantitative SRM-MS: Double the Speed or Double the Trouble? Enabling Nanospray in Triple-Quad Mass Spectrometry Biologics Discovery & Characterization Can LC-MS/MS Play a Role in Biologics Development Without Solving the Sample Preparation Issue? Direct Characterization of Biotherapeutic Aggregation and Other Protein Interactions Using High Mass MS |
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2:15 pm - 3:30 pm | Symposia & Rountable Discussion |
Does LC/MS/MS Assay Have a Place in Biologics Development?
The Rapid Integration of LC-MS-based Bioanalytical Methods to Quantify Peptides Therapeutics in Drug Discovery Challenges & Solutions in the Quantitative Analysis of Large Therapeutic Peptides Large Therapeutic Proteins Quantification: The Best of Both Worlds Roundtable Discussion | |
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3:45 pm - 5:30 pm |
Vendor Session - "Five minutes of fame!" |
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5:30 pm - 6:30 pm |
Exhibition & Social Hour |
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6:30 pm - 9:00 pm |
CPSA Dinner Announcements CPSA Shanghai 2012
Food Quality & Safety Summit
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Keynote Dinner Lectures Liquid Chromatography-Mass Spectrometry in Pharmacology Research and its Transition to Clinical Applications Ian Blair, University of Pennsylvania Distinguished Analytical Scientist Award A Scientific Adventure—LC/MS: From Academia to Entrepreneurship |
Thursday, October 6 | |
7:30 am - 8:30 am | Registration & Continental Breakfast |
8:30 am - 4:00 pm | Short Course Is Bioavailability in Early Drug Discovery a Problem and if so, How Can We Fix It? |
8:30 am - 10:00 am | Symposia & Roundtables
CRO-Innovator Interface Discovery and Development Bioanalysis Outsourcing: Similarities, Contrast, and Challenges Method Transfer Between Labs: The Challenges and Pitfalls
Bioanalytical Offshore Outsourcing - Strategies and Challenges
Whose SOPs? Ours or Yours?
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10:15 am - 11:45 am |
New Technologies
Towards Nanospray for High Throughput Mass Spectrometry
Exploiting the Orthogonality of Differential Mobility in LC-MS Analysis
Cells Instead of Microsomes. Why the HepRG Cell Line is Going to Revolutionize DMPK Screening
The Emerging Role of Zebrafish Embryo Models in Toxicology |
12:00 pm - 1:15 pm |
Sponsored Lunch & Roundtables
Coupled Workflows Enabled by HRMS: How Can We Acquire Integrated Datasets? Overview of Qual/Quant: What It Is and What It Is Not. A Specific Example. Informatics Considerations for Enabling Global Data Management |
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1:15 pm - 3:00 pm |
Symposia & Roundtables Clinical Diagnostics: From Biology to Analytical Chemistry Early Detection of Biomarkers for Pancreatic Cyst Management Anthony Yeung, Fox Chase Cancer Center Strategy, Specimens, Sensitivity, Selectivity and Success in the Development of Clinical Diagnostic Assays Melissa Johnson, Duke University Medical Center Life Lessons in a Clinical Diagnostic Lab Bingfang Yue, NMS Labs |
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3:00 pm - 4:00 pm |
Closing Event Hosted by PharmaCadence The Flavorful Chemistry of Chocolate The alluring aroma and complex taste of cocoa is a result of a collection of molecules that we perceive as they interact with our nasal olfactory epithelium and taste receptors in our oral cavity. In addition to its unique flavor, cocoa contains a wealth of phytonutrients known as cocoa flavanols, which are increasingly recognized for their beneficial effect on human health. Due to the complex nature and diversity of these molecules, different arrays of analytical techniques are required for their analysis. This talk will highlight chocolate flavor, the diversity of natural products found in cocoa, and several different analytical techniques used in studying the flavorful chemistry of chocolate. |