Poster #01
ADDA: A new LC/MS/MS sample delivery platform for drug discovery bioanalysis
John Janiszewski¹, Rick Schneider¹, Veronica Zelesky¹, Brendon Kapinos¹, Hui Zhang¹, Matt Troutman¹, Nick Levitt², Jack Zhou², Wayne Lootsma³, Will Schramm³ and Felix Yiu²
1) Pfizer Global Research and Development, Groton, CT USA; 2) Apricot Designs, Covina, CA USA; 3) Sound Analytics, Niantic, CT USA

Poster #02
Qualification of a Robotic Liquid Handler to Perform Bioanalytical Validation or Sample Analysis Runs
Ron Shoup
AIT Bioscience, LLC, Indianapolis, IN USA

Poster #03
Achieving Regulatory Approval: Overcoming Bioanalytical Challenges in an Onglyza™ Micro-tracer Absolute Bioavailability Study with Accelerator Mass Spectrometry
Xiaohui (Sophia) Xu¹, Lisa J. Christopher¹, Stephen Dueker², Pete Lohstroh², Vikram Roongta³, Laura Cojocaru⁴, Chi Fung (Anther) Keung¹, W. Griffith Humphreys¹, Bruce Stouffer¹ and Mark Arnold¹
1) Bristol-Myers Squibb, Princeton, New Jersey USA; 2) Vitalea Sciences, Inc, Davis, CA USA; 3) roongtav2@embarqmail.com; 4) Tandem Labs, West Trenton, NJ USA

Poster #04
Comparison of Microsampling Techniques for Quantitative DBS and DPS Preparation
Jim Kenney¹, Joe Siple¹, Chris Strohsahl²
1) Drummond Scientific Company; 2) University of Rochester

Poster #05
Development of a bioanalytical DBS assay using a tandem quadrupole with a novel collision cell design
Joanne Mather, Paul Rainville, Debadeep Bhattacharya, and Rob Plumb
Waters Corporation, Milford, MA

Poster #06
Comprehensive Study Examining Interfering Compounds from Various Dried Blood Spot Cards and Extraction Solvents with ESI Positive Tandem Quadrupole MS
Jennifer Simeone¹; Chester L Bowen²; Joanne Mather¹; Robert Plumb³; Debadeep Bhattacharya¹; Paul Rainville¹
1) Waters Corporation, Milford, MA USA; 2) GlaxoSmithKline, King Of Prussia, PA USA; 3) Imperial College, London, United Kingdom

Poster #07
LC/MS/MS Quantification of Fluticasone Propionate in Human Plasma at the fg/mL Level
Joanne Mather, Kendon Graham, Debadeep Bhattacharya, and Rob Plumb
Waters Corporation, Milford, MA

Poster #08
A Direct LC-MS/MS Method for Determination of ß-Alanine in Human Plasma
Qian (Cynthia) Chen, Connell Cunningham, Julie E. Eble
Critical Path Services, Garnet Valley, PA USA

Poster #09
The Separation of Basic Analytes on a Polar-modified C18 HPLC Stationary Phase
David W. House, Asha A. Oroskar, and Anil R. Oroskar
Orochem Technologies, Inc.

Poster #10
"Mass Spec friendly" Plastics Safe for Quantitative Mass Spectrometry Analysis
Igor Gavin, Naveen Sudharsan, Deepak Sharma, Asha A. Oroskar, and Anil R. Oroskar
Orochem Technologies Inc., Lombard, IL USA

Poster #11
A Novel High Throughput Method Using Full Scan HRAM and Online Extraction for Plasma Protein Binding Determination
Kevin Cook, Mark Dreyer, Keeley Murphy, Nicholas Duczak
Thermo Fisher Scientific, San Jose, California, USA

Poster #12
Quantitation of metabolites in plasma samples by UV-MS correction using a dual-cell-linear ion trap mass spectrometer
Tim Stratton, Yingying Huang, August Specht, Julie Horner
Thermo Fisher Scientific, San Jose CA USA

Poster #13
Optimization of Nanospray Voltage and Spray Stability: Impact on Chromatographic Peak Area for Analyte Quantitation
Amanda Berg¹; Mike S. Lee²; Gary Valaskovic¹
1) New Objective, Inc., Woburn, MA USA; 2) Milestone Development Services, Newtown, PA USA

Poster #14
Evaluation of 150 µm ID Packed Tip Columns for Quantitative Peptide Analysis by LC-MS/MS
Stanley Durand; Helena Svobodova; Amanda Berg; Gary Valaskovic
New Objective, Inc., Woburn, MA USA

Poster #15
Development and Validation of a Method for the Determination of a Genetic Fusion Protein in Human Plasma using UHPLC-MS/MS for First Time in Human (FTIH) Study Support
Bonnie Orr, Matthew Szapacs, Jonathan Kehler, Chester Bowen
GlaxoSmithKline Pharmaceuticals, King of Prussia, PA USA

Poster #16
Multiplexing SIMs on a Novel Benchtop Orbitrap MS with a Quadrupole Mass Filter to Increase Sensitivity for Peptide Quantitation
Kevin L. Cook, Patrick Bennett, Nicholas Duczak, Louis Maljers
Thermo Fisher Scientific, San Jose, California, USA

Poster #17
Analysis of a Therapeutic Antibody and a Biomarker in Parallel Utilizing Immunocapture and LC-MS/MS
Neha Akella, Jonathan Kehler, Matthew Szapacs and Scott Hottenstein
GlaxoSmithKline Pharmaceuticals, King of Prussia, PA USA

Poster #18
A Sensitive Assay for the Measurement of Endogenous Levels of Angiotensin Peptides as a Biomarker Utilizing HPLC-MS/MS Detection
Jonathan Kehler, Matthew Szapacs and Neha Akella
GlaxoSmithKline Pharmaceuticals, King of Prussia, PA USA

Poster #19
Overcoming the challenges in targeted and non-targeted metabolite profiling of myxobacterial secondary metabolites using UHR-Q-TOF-MS analysis
Daniel Krug¹; Nina Cortina¹; Gabriela Zurek²; Aiko Barsch²; Verena Tellström²; Rolf Mueller¹
1) University of Saarbruecken, Saarbruecken, Germany; 2) Bruker Daltonik, Bremen, Germany

Poster #22
Using UPLC-QuanTOF technologies and chemically intelligent software tools for confident metabolite identification and biotransformation localization in discovery and development
Mark D. Wrona¹, Stephen McDonald¹, Jeff Goshawk², Alan Millar¹
1) Waters Corporation, Milford, MA USA; 2) Waters Corporation, Manchester, United Kingdom

Poster #23
Identification of a complicated metabolite for a GSK drug candidate using the structure identification tool box
Min Lin, Jill Pirhalla, Steve Castellino
GlaxoSmithKline, King of Prussia, PA USA

Poster #24
High-resolution accurate mass-measurements and metabolite identification: an automated approach using fragment prediction in combination with fragment ion search (FISh)
Paul-Gerhard Lassahn¹, Rose Herbold², Tim Stratton²
1) Swiss BioAnalytics AG, Birsfelden, Switzerland, 2) Thermo Fisher Scientific, San Jose CA USA

Poster #25
Application of a Novel Bench-top Orbitrap Mass Spectrometer with a Quadrupole Mass Filter for Metabolite Profiling in Drug Discovery
Qian Ruan¹; Kate Comstock²; Li Ma¹; Tim J Stratton²; Yingying Huang ²; Mingshe Zhu¹
1) Bristol-Myers Squibb, Princeton, NJ USA; 2) Thermo Fisher Scientific, San Jose CA USA

Poster #26
By-products in recombinant TAU protein production characterized by LC-MALDI Top-Down Sequencing (LC-MALDI-TDS)
Arndt Asperger¹, Marcus Macht¹, Branislav Kovacech², Andrej Kovac²
1) Bruker Daltonik, Bremen, Germany; 2) Institute of Neuroimmunology of Slovak Academy of Sciences, Bratislava, Slovakia

Poster #27
Development of a Methodology for Rapid Characterization of Biological Therapeutics
M. Willetts¹, G. Tremintin², C. Albers³, L.C. Main⁴, C. Baessmann³, W. Jabs³
1) Bruker Daltonics, Billerica, MA; 2) Bruker Daltonics, Fremont, CA; 3) Bruker Daltonik, Bremen, Germany; 4) Bruker Daltonics, Coventry, UK

Poster #28
Automatic MS/MS characterization of N-linked Glycopeptides
Andrea Kiehne, Anja Resemann, Ulrike Schweiger-Hufnagel, Arndt Asperger, Detlev Suckau
Bruker Daltonik, Bremen, Germany

Poster #20
Comparison of Accurate Mass and Nominal Mass MSMS for the Simultaneous Acquisition of Qualitative and Quantitative Data in DMPK Studies
Joanne Mather, Marian Twohig, Hilary Major, Paul Rainville, Debadeep Bhattacharya, and Robert S. Plumb
Waters Corporation, Milford, MA, USA

Poster #21
Simultaneous Determination of Metabolic Stability, Metabolite Identification and Profiling Using the Agilent 6550 iFunnel Q-TOF LC/MS System
Yuqin Dai, Michael Flanagan, and Keith Waddell
Agilent Technologies, Inc., Santa Clara, CA USA

Poster #29
A simple and effective tube construct for salty samples in cryoprobes
István Pelczer
Princeton University, Princeton, NJ USA

Poster #30
Fundamental Characteristics of Small Molecule Analysis using Ultra Low Dynamic Flow
Ben Ngo¹; Shaoxia Yu²; Mike S. Lee³; Jing-Tao Wu²; Gary Valaskovic¹
1) New Objective, Inc., Woburn, MA USA; 2) Millennium Pharmaceuticals, Inc., Cambridge, MA USA; 3) Milestone Development Services, Newtown, PA USA

Poster #31
High Throughput Screening for Lead Discovery using Multiplexed LC with High Resolution Accurate Mass LC/MS
Keeley Murphy, Nick Duczak, Francois Espourteille
Thermo Fisher Scientific, San Jose, CA USA

Poster #32
Rapid Chemical ID using a Direct Analysis in Real Time Mass Spectrometry using a Heated Sample Screen in the ID-CUBE™
Brian Musselman¹, Jordan Krechmer¹, Joseph Tice¹, and Zhongli Zhang²
1) IonSense, Inc., Saugus, MA USA; 2) IonSense, Inc. Visiting Scientist

Poster #33
Using Electronic Lab Notebook Functionality for Validating Electronic Lab Notebook Workflows
Brian Beato, Tim Grever and Laurel Branstrator
AIT Bioscience, Indianapolis, IN USA

Poster #34
Strategy for Designing Electronic Lab Notebook Workflows Both Flexible Enough for R&D and Comprehensive Enough for Regulated Work
Brian Beato, April Pisek and Jessica White
AIT Bioscience, Indianapolis, IN USA

Poster #35
Efficient Strategy for Generating Method-Specific Workflows in an Electronic Lab Notebook
Brian Beato, Jessica White and April Pisek
AIT Bioscience, Indianapolis, IN USA

Poster #36
Advances in the Automated Data Analysis of High Resolution Accurate Mass LC-MS Metabolomics
Serhiy Hnatyshyn¹, Petia Shipkova², Michael Reily¹, Mark Sanders³
1) Bristol-Myers Squibb Co., Lawrenceville, NJ, USA; 2) Bristol-Myers Squibb Co., Pennington, NJ, USA; 3) Thermo Fisher Scientific, Somerset, NJ USA

Poster #37
Automated Deisotoping and Charge Deconvolution of High-Resolution LCMS Data
Mark E. Hail¹ and Stuart Ray²
1) Novatia, LLC, Monmouth Junction, NJ; 2) Positive Probability, Ltd., UK

Poster #38
Mass Spectral Structure Elucidation and Correlation Algorithm Based Upon Advanced Graph Theory Methods
Marshall M. Siegel
MS Mass Spectral Consultants, Fair Lawn, NJ USA