Chemical & Pharmaceutical Structure Analysis
Where Technology and Solutions Meet

CPSA 2011

Science and Technology Coming Together to Make a Difference

October 3 - 6, 2011
Bucks County Sheraton Hotel
Langhorne, PA


Poster Abstract #10

"Mass Spec friendly" Plastics Safe for Quantitative Mass Spectrometry Analysis

Igor Gavin, Naveen Sudharsan, Deepak Sharma, Asha A. Oroskar, and Anil R. Oroskar

Orochem Technologies Inc., 331 Eisenhower Lane South, Lombard, IL 60148 USA

The use of high-quality materials in sample preparation is critical for analytical applications using mass spectrometry. Leaching of chemicals from plastic and/or rubber may contaminate samples resulting in appearance of additional peaks in mass spectra which interfere with analyte analysis. We developed a quality control procedure for plastic consumables used in mass spectrometry and evaluated plastic products manufactured by a number of vendors. We detected significant contamination in methanol, acetone or acetonitrile washes from plastic products acquired from some vendors. The contamination was also present when consumables were pre-washed with water suggesting that chemicals were extracted from plastic by the organic solvents. To develop a product line of consumables for mass spectrometry applications we identified ways of effectively removing contamination from plastic. These “mass spec-friendly” plastics do not require conditioning and do not contaminate samples and therefore can be safely used in all analytical protocols including mass spectrometry analysis.

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